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Opiates and opioids bind to opioid receptors within the Mind and spinal cord. As a result, they alter the user's perception of pain.This OxyContin ER beat the hell from any prior combination even my doubling up of very potent Dilauded 8mgs. I could not travel in the least. I waited 48 hrs just before I returned to earth. (ER-Prolonged Release)The i